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ID 14191
Eprint ID
14191
FullText URL
Thumnail 104_1.pdf 903 KB
Title Alternative
Clinical significance of Creola body in the sputum of bronchial asthmatics
Author
Isoshima, Koji
Abstract
To examine the clinicopathology of agglomerated bronchial epithelial cells, i. e. Creola body (CrB), in the sputum, the incidence of CrB stained by Papanicoloaou's method was evaluated in 46 bronchial asthmatics and 10 patients with obstructive pulmonary diseases, and then was compared with the pathogenetic factors of bronchial asthma. CrB was observed specifically in the sputum of bronchial asthmatics. CrB-positive cases had asthma attacks for more than 4 days and a high incidence of eosinophils in the sputum, but not CrB-negative cases. The presence of CrB in the sputum tended to be high in non-atopic asthmatics with a low serum IgE level, but had no significant correlation with either the incidence of neutrophils in the sputum, the present age of patients, the severity of the disease or bronchial hyperresponsiveness to acetylcholine. These findines suggest that the involvement of histolesional factors such as persistent bronchial contraction and release of major basic protein from eosinophils in the airway may lead to the formation of CrB. Also the appearance of CrB may be a useful index for pre-serious stage of asthma.
Keywords
bronchial asthma
sputum
Creola body
eosinophil
neutrophil
Published Date
1992
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1
End Page
9
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/1-2/104_1-2_1/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma