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ID 14172
Eprint ID
14172
FullText URL
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Title Alternative
Chemical and physiological changes of serum and thoracic-duct lymph in the dog with experimental obstructive jaundice and/or disorder of liver circulation
Author
Ueda, Yuzo
Abstract
A long-term study on the chemical and physiological changes of serum and thoracic-duct lymph in the dog with a ligated common bile duct and/or artificial liver circulation was performed. The influencee of ligation of the common bile duct appeared earlier in the thoracic-duct lymph than in the serum. The portal pressure did not increase in the dog with a ligated common bile duct, but the lymph flow of the thoracic duct was 3 times that before ligation, which would prevent the rapid stagnation of bile pigment in the liver. The portal pressure was not elevated after ligation of the hepatic artery. The cholesterol level in the thoracic-duct lymph was about half of that in the serum. In the dog with ligature of the common bile duct, the serum total cholesterol level was elevated with the elevation of serum bilirubin, whereas that in the lymph of the thoracic duct was not elevated with the elevation of the bilirubin level in the lymph. These findings suggested that cholesterol would not easily enter into the lymphatic route. The serum GPT level increased during the first week after ligation of the hepatic artery, and decreased thereafter. However, after ligation of the common bile duct, the GPT level increased for several weeks after the first week of ligation. The pattern of GPT by both ligations seemed to be cross-crossed. The marked change in the total bilirubin level in the lymph of the thoracic duct suggested its close relation with the lymphatic system. It was proved possible to secure a tube into the thoracic duct for over three weeks by the use of a U-type connector and jacket-type plaster cast.
Keywords
実験的肝障害
閉塞性黄疸
肝循環障害
胸管リンパ液
胸管カヌレーション
Note
原著
Published Date
1992-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
747
End Page
761
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_747/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
References
1) 日本実験動物研究会:実験動物テキスト(第一版).東京(1971).
2) 田嶋嘉雄:実験動物学(各論).朝倉書店,東京(1973)pp174-184.
3) 福井正信,友田 勇,上田雄幹:実験用ビーグルの研究.ソフトサイエンス社,東京(1976)pp75-97.
4) 大本誠二:実験外科ハンドブック.医学書院,東京(1967)pp273-311.
5) 長瀬すみ,田中寿子:実験動物の臨床生化学データ.ソフトサイエンス社,東京(1976)pp159-284.
6) 吉利和也,中尾喜久,山形敞一,三辺 謙,黒岩義五郎,織田敏次,山村雄一:新内科学大系20.中山書店,東京(1976)pp168-173.
7) 吉利和也,中尾喜久,山形敞一,三辺 謙,黒岩義五郎,織田敏次,山村雄一:新内科学大系20.中山書店,東京(1976)pp3-8.
8) 三辺 謙:肝疾患と胸腹水.臨研(1969)46,48-55.
9) 島田宣浩:腹水の成因とその対策.薬局(1978)29,85-90.
10) 小林迪夫,楊 総三,朔 元則,小川雄一郎,井口 潔:腹水と胸管リンパ流.外科(1972)34,571-577.
11) 志村秀彦:胸腹水の外科的治療.臨研(1969)46,96-100.
12) 越川昭三:腹水.日臨(1972)30,226-227.
13) Pickert H : Uber Entstehung und Wesen des Aszites. Medizinische Klinik (1967) 62, 1493-1499.
14) Mckee FW, Schilling JA, Tishkoff GH and Hyatt RE : Experimental Ascites. SGO (1949) 89, 529-539.
15) Orloff MJ and Snyder GB : Experimental Ascites. Surgery (1961) 50, 220-230.
16) 堀井五十雄:肝臓とリンパ球.最新医(1956)11,89-97.
17) 西丸和義,八田博英:肝臓と肝臓リンパ管,リンパ流,リンパ液について.最新医(1956)36,97-103.
18) 西村宏明:放射性ヨウ化人血清アルブミンによる肝リンパ動体の研究.日放会誌(1976)36,6-17.
19) 野間口民男:人胎児ならびに哺乳動物における肝臓リンパ管系の比較解剖学的研究.熊本医誌(1955)29(補冊第1),118-133.
20) 島田宣浩,小林敏成,前田種雄,木津裕州,橋本宏之,名和 伸,糸島達也:肝リンパ管に対する腹腔鏡的研究.肝臓(1966)7,52-57.
21) 奥平雅彦:肝リンパの流路.医の歩み(1950)69,256-257.
22) Horace DR : Flow of lymph from the canine liver. Am J Physiol (1959) 196, 105-109.
23) 田路良博:胸管あるいは後腹膜リンパ系の通過障害におけるリンパ系のレ線学的研究.日放会誌(1969)29,12-32.
24) 師田 昇:外科的侵襲時の血管系物質吸収能変化に関する実験的研究.東京医学雑誌(1959)67,600-630.
25) Bede M : The Hepatic and Intestinal Contributions to the Thoracic Duct Lymph. Qua J Exp Biol (1956) 41, 318-325.
26) 高橋 淳:実験的肝Out flow block におけるリンパの変化.日消病会誌(1969)66,53-65.
27) 山崎善弥:腹水症,胆道閉鎖症と肝内外リンパ系の関係について.日外会誌(1965)66,1931-1955.
28) 鈴木雅洲,渡辺 侃:胸管リンパの基礎と臨床.総合臨(1969)18,1976-1982.
29) 八田博英:リンパ管およびリンパ液の流れ(Ⅰ).広島医(1960)13,15-19.
30) 八田博英:リンパ管およびリンパ液の流れ(Ⅱ).広島医(1960)13,11-17.
31) 八田博英:リンパ管およびリンパ液の流れ(Ⅲ).広島医(1960)13,11-20.
32) 八田博英,岡田乾一:リンパ生成における肝臓の役割について.日生理誌(1954)16,629-630.
33) 入沢 宏:リンパ液.総合医学(1955)12,27-32.
34) 水沢英甫:Esverivenの胸管リンパ流増大作用.現代の臨床(1968)2,116-118.
35) 岡田乾一:Ringer 氏液静脈注入の右リンパ総管リンパへの影響について.広島医原著号(1954)2,114-117.
36) Dumont AE, Witte CL, Witte MH and William RC : Origin of Red Blood Cells in Thoracic Duct Lymph in Hepatic Cirrhosis. Ann Srurg (1970) 171, 1-8.
37) Dumont AE and Mulholland JH : Flow Rate and Composition of Thoracic Duct Lymph in Patients with Cirrhosis. N Engl J Med (1960) 263, 471-474.
38) Dumont AE, Doubilet H, Witte CL and Mulholland JH : Disorders of the Biliary-Pancreatic System. Ann Surg (1961) 153, 774-780.
39) Dumont AE : Experimental biliary obstruction. Am J Physiol (1962) 202, 704-706.
40) Dumont AE and Witte MH : Contrasting Patterns of Thoracic Duct Lymph Formation in Hepatic Cirrhosis. SGO (1966) 104, 524-528.
41) Dumont AE, Witte CL and Witte MH : Studies of Lymph in Certain Disorders of the Liver, Pancreas and Small Intestine. Am J Gastroenterol (1971) 56, 346-351.
42) Dumont AE : Icteric Thoracic Duct Lymph. Ann Surg (1973) 178, 53-58.
43) Dumont AE and Mulholland JH : Effects of thoracic duct to esophagus shunt in dogs with vena caval constriction. Am J Physiol (1963) 204, 289-290.
44) Nix JT, Mann FC, Bollman JL, Grindlay JH and Flock EV : Alterations of Protein Constituents of Lymph by Specific Injury to the Liver. Am J Physiol (1951) 164, 119-122.
45) Niels M, O'Keefe D and Welch CS : Thoracic duct lymph flow with variations in hepatic hemodynamics. Surgery (1964) 56, 1121-1128.
46) 千野宗之進:流血中および胸管リンパ液中腫瘍細胞の検索.日外会誌(1969)70,1615-1642.
47) 曲田公光:頚部廓清術における頸部胸管の形態に関する臨床的研究.日耳鼻(1969)72,106-121.
48) Takashima : Lymphatico-venous communications and lymph reflex after thoracic duct obstruction. Invest Radiol (1966) 1, 188-197.
49) Takashima : Experimental Thoracic Duct Obstruction in Dogs. Jpn Circ J (1970) 34, 387.
50) 向尾軍平:人および哺乳動物における胸管起始ならびにこれに関与するリンパ管系について.熊本医会誌.(1954)28,790-801.
51) Lee FC : The establishment of collateral circulation following ligation of the thoracic duct. Bulljohns Hopkins Hospital (1922) 33, 21.
52) Cremer H, Muller N and Bechtelsheimer H : Morphological Studies on the Rat Liver and a Biochemical Analysis of the Serum Following Experimental Ligature of the Thoracic Duct. Lymphology (1974) 7, 69-80.
53) 山田 喬:ダイコクネズミ胸管より持続的多量リンパ球採取法.医のあゆみ(1966)56,234-238.
54) 有松祥雄,谷川久一,奥田邦雄:ダイコクネズミの胸管リンパ採取法.医のあゆみ(1969)69,535-537.
55) 庵原昭一,綿貫重雄,奥井勝二,岩瀬亀夫,千野宗之進,原 久弥,藤田昌宏,伊藤文雄,香西 襄:胸管内リンパ液の採取法と細胞診.日臨細胞会誌(1967)6,4-5.
56) 正岡 昭:胸管ドレナージ.胸部外科(1977)30,608-611.
57) Inokuchi K and Kusada A : Thoracic Duct-Jugular Venous Anastomosis for Intractable Hepatic Ascites or Terminal Stage of Cirrhosis ; in Atlas of Applied Vascular Surgery (1976) 148-152.
58) Kawai T, Stoitchcov E, Lorenzini C, Merle M and Benichoux R : Long-Term Follow-Up of Dogs, with a Patent Anastomosis of the Thoracic Duct to the Esophagus. Eur Surg Res (1974) 6, 46-55.
59) Bollman JL : Techniques for the Collection of Lymph from the Liver, Small Intestine or Thoracic Duct of the Rat. J Lab Clin Med (1948) 33, 1349-1352.
60) Cain JC, Grindlay JH, Bollman JL, Flock EV and Mann FC : Lymph from Liver and Thoracic Duct. SGO (1947) 85, 559-562.
61) Wegria R, Zekert H, Walter KE, Entrup RW, Schreyver CD, Kennedy W and Paiewonsky D : Effect of systemic venons pressure on drainage of lymph from thoracic duct. Am J Physiol (1963) 204, 284-288.
62) Clauss RH and Breed ES : Controlled Rate of Drainage of Thoracic Duct Lymph. Am J Surg (1970) 119, 610-612.
63) Raju S : Technic for the Creation of a Thoracic Fistula in the Dog. Am J Surg (1974) 127, 256-257.
64) Ellis FG : A technique for intermittent collection of thoracic duct lymph. Surgery (1966) 60, 1251-1253.
65) 土井淳愛:実験的門脈圧亢進症における腹水形成に関与するリンパ系の役割について.日消病会誌(1965)62,631-654.
66) 永田 弘:肝前性門脈狭窄時における門脈副血行路形成に関する実験的研究.名医学(1957)73,691-731.
67) 上原従正:門脈圧亢進症の発生原因に関する研究.肝臓(1972)13,606-615.
68) 江崎治夫:門脈圧亢進症について.広島医(1960)13,1-10.
69) 芝山雄老:コリン欠乏性肝硬変ラットにおける門脈圧亢進の発生原因.肝臓(1975)16,10-18.
70) Witte CL : Lymph Protein in Hepatic Cirrhosis and Experimental Hepatic and Portal Venons Hypertention. Ann Surg (1968) 168, 567-577.
71) 比田井耕,島 文夫,市原荘六,二川俊二,杉浦光雄,石田正統:門脈圧亢進症.綜合臨(1974)23,1019-1026.
72) 斉藤秀偉:いわゆる肝静脈閉塞症に対する門脈側副血行路造設手術に関する研究.名医学(1958)76,56-71.
73) 飯田 豊:胸腔内下大静脈急性閉塞に関する実験的研究.岡山医誌(1958)71,1145-1153.
74) 伊達政照:門脈再建に関する実験的研究.日外宝(1960)29,1667-1689.
75) 森野 勝:門脈再建に関する実験的研究.日外宝(1961)30,1-19.
76) 日置康生:門脈移植に関する実験的研究.大阪大医誌(1977)36,37-53.
77) 西本勝美:門脈再建に関する実験的研究.日外宝(1960)29,1692-1709.
78) 大歳栄一,水本龍二,本庄一夫:肝切除と肝動脈遮断.日外宝(1977)46,681-688.
79) Fraser D, Rappaport AM, Vuylsteke CA and Colwell AR : Effect of the Ligation of the Hepatic Artery in Dogs. Surgery (1951) 30, 624-640.
80) Laufman H : Graded Hepatic Arterial Ligations in Experimental Ascites. SGO (1953) 96, 409-419.
81) Lee YN : Liver Function Tests After Ligation of Hepatic Artery. J Surg Oncol (1978) 10, 305-320.
82) Hockerstedt K : Liver Hilus Dearterialization. Ann Chir Gynaecol (1978) 67, 217-223.
83) 田中幹夫:肝外閉塞性黄疸発生におけるリンパ系の関与.肝臓(1966)7,58-65.
84) 岸 明宏:先天性胆道閉鎖症の外科治療に関する研究.広島大医誌(1974)22,213-250.
85) 林慎一郎,平松誠子:胆管酵素の血中上昇の機序.肝臓(1973)14,36-39.
86) Witte MH, Dumont AE and Levine N : Pattern of Distribution of Sulfobromophthalein in Lymph and Blood during Obstruction to Bile Flow. Am J Surg (1968) 115, 69-74.
87) Aronsen KF : Liver Function studies during and after complete extrahepatic biliary obstruction in the dog. Acta Chir Scand (1961) 275, 1.
88) Romieu C and Brunschwig A : Bacteriologic study of the human liver. Surgery (1951) 30, 621-623.
89) 酒井昭義:肝循環動態に関する研究.日外会誌(1960)61,551-575.
90) 加藤 泰:肝循環障害の実験的研究.日外会誌(1968)69,279-299.
91) 菊池武雄:肝循環動態の実験的研究.肝臓(1969)10,219-233.
92) 解良白皐:肝疾患における門脈および肝動脈血流の測定.肝臓(1971)12,389-395.
93) 川部克己,横田 峻,水本龍二,本庄一夫:肝血行動態の実験的研究.日外宝(1977)46,551-562.
94) 山本貞博:肝血流量測定と肝疾患.診療(1970)23,229-234.
95) 高橋邦明:肝疾患とくに慢性肝炎における肝循環動態に関する研究.岩手医誌(1971)23,8-23.
96) 寺中正昭:ショック時における肝臓の血行動態と機能に関する研究.日外会誌(1978)79,216-229.
97) 島田宣浩:経臍静脈門脈カテーテル法による肝動脈,門脈血流量比の測定.肝臓(1969)10,547-552.
98) 中田勝次:肝循環.肝臓(1968)9,219-227.
99) 山中功二,水本龍二,大沢二郎,河野有朋,横田 峻,本庄一夫;胆汁異常と肝血行動態の変動.肝臓(1973)14,2-5.
100) 石川兵衛,松井宏照,本庄 昭,林  需,松島昭彦,進藤敬久,岡林正純:肝循環に関する研究.奈良医誌(1975)26,446-451.
101) Moreno AH, Burchell AR, Reddy RV, Panke WF and Nealon TF : The Hemodynamics of portal hypertension revisited : Determinants and significance of occluded portal pressures. Surgery (1975) 77, 167-179.
102) MacDonald AC, Marble AE and Perkins JG : Hepatic Blood Flow and Metabolism. Arch Surg (1979) 114, 616-621.
103) Bruton-Opitz R : The Vascularity of the Liver. Q J Exp Physiol (1911) 4, 93-102.
104) Kock NG, Hahnloser P, Poding B and Schenk WG : Interaction between portal venous and hepatic arteraial blood flow. Surgery (1972) 72, 414-419.
105) Schenk WG, McDonald JC, McDonald K and Drapanas T : Direct Measurement of Hepatic Blood Flow in Surgical Patients. Ann Surg (1962) 156, 463-471.
106) Greenway CV and Oshiro G : Intrahepatic Distribution of Portal and Hepatic Arterial Blood Flows in Anesthetized Cat and Dogs and the Effects of Portal Occlution, Raised Venous Pressure and Histamine. J Physiol (1972) 227, 473-485.
107) Shafey OA and Hassab MA : Experimental study on hemodynamics of hepatic arterial and portal venous flow. Surgery (1968) 63, 962-965.
108) Hanson KM and Johnson PC : Local control of hepatic arterial and portal venous flows in the dog. Am J Physiol (1966) 211, 712-720.
109) Roy C and Kountz S : Factors influencing control of arterial circulation in the river of the dog. Am J Physiol (1963) 205, 1260-1264.
110) Takeuchi J, Kubo T, Tone T, Takada A, Kitagawa T and Yoshida H : Autoregulation and interaction between two vascular systems in dog liver. J Appl Physiol (1969) 27, 77-82.
111) Ternburg JL and Butcher HR : Blood-Flow Relation between Hepatic Artery and Portal Vein. Science (1965) 150, 1030-1031.
112) Ackroyd FW, Mito M and McDermott WV : Autonomic Vasomotor Controls in Hepatic Blood Flows. Am J Surg (1966) 112, 356-362.
113) Muller W and Smith LL : Hepatic Arterial and Portal Venous Circulatory Changes Following Hemorrhage in the Dog. SGO (1963) 101, 753-758.
114) Price JB, McFate PA and Shaw RF : Dinamics of blood flow through the normal canine liver. Surgery (1964) 56, 1109-1120.
115) Macleod JJR and Pearce RG : The out flow of Blood from the Liver as Affected by Variations in the Condition of the Portal Vein and Hepatic Artery. Am J Physiol (1914) 35, 85-105.
116) Drapanas T, Kluge DN and Schenk WG : Measurement of Hepatic Blood Flow by BSP and by the Electromagnetic Flow meter. Surgery (1960) 48, 1017-1021.
117) Green HD, Hall LS, Sexton J and Deal CP : Autonomic vasomotor responses in the canine hepatic atrerial and venous beds. Am J Physiol (1959) 196, 196-202.
118) Blalock A and Mason MF : Observations on the Blood Flow and Gaseous Metabolism of the Liver of Unanesthelized Dogs. Am J Physiol (1936) 117, 328-334.
119) 山崎三省:代謝異常;病気の生化学,中山書店,東京98-123.
120) Starling : The influence of mechanical factors on the lymph production. Am J Physiol (1894) 16, 224.
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joma