このエントリーをはてなブックマークに追加
ID 14094
Eprint ID
14094
FullText URL
Thumnail 106_549.pdf 6.83 MB
Title Alternative
Clinical studies on plasma cyclic nucleotide levels in acute leukemia
Author
Nonaka, Kenichi
Abstract
Plasma levels of cyclic nucleotides were measured in 71 patients with acute leukemia [50 patients with acute nonlymphocytic leukemia (ANLL), five patients with hypoplastic leuke-mia, and 16 patients with acute lymphocytic leukemia (ALL)], five patients with myelodysplas-tic syndrome (MDS), and 47 healthy volunteers. The cyclic GMP (c-GMP) level, cyclic AMP (c-AMP) level, and c-AMP/c-GMP ratio in healthy volunteers were 15.74±5.10 pmol/ml, 3.20±1.15 pmol/ml and 5.39±2.18, respectively. In the patients with untreated acute leukemia other than hypoplastic leukemia, c-GMP levels were significantly elevated (ANLL : 11.31±13.61 pmol/ml ; ALL : 10.66±7.23 pmol/ml) and c-AMP/c-GMP ratios were significantly reduced (ANLL : 2.01±1.03 ; ALl : 1.66±1.03). These values normalized at remission, than increased or decreased again with recurrence of the disease. Although patients with MDS showed normal c-GMP levels or c-AMP/c-GMP rations, these values were increased or decreased when progression to acute leukemia occurred. There was correlation between c-GMP levels and peripheral leukocyte counts (r=0.429,p<0.05), plasma c-GMP levels and peripheral leukemic cell counts (r=0.412,p<0.05), c-AMP/c-GMP rations and peripheral leukocyte counts (r=-0.577,p<0.05), c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and periph-eral leukemic cell counts (r=-0.512,p<0.05), and c-AMP/c-GMP rations and maximum counts of colonies derived from leukemic blast progenitors (r=-0.996,p<0.01). Since plasma levls of cyclic nucleotides reflect the leukemic cell proliferation, measurement of these nucleotides was considered useful for monitoring leukemic cell volume.
Keywords
血漿 cyclic nucleotides
急性白血病
低形成型白血病
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
549
End Page
560
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/5-6/106_5-6_549/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
References
1) Rall TW and Sutherland EW : Formation of cyclic adenine ribonnucleotide by tissue particles. J Biol Chem (1958) 232, 1065-1076.
2) Ashmann DF, Lipton R, Melicow MM and Price TD : Isolation of adenosine 3',5'-monophosphate and guanosine 3',5'-momophosphate from rat urine. Biochem Biophys Res Commun (1963) 11, 330-334.
3) Murad F, Manganiele V and Vanughan M : A simple, sensitive protein-binding assay for guanosine 3',5'-monophosphate. Proc Natl Acad Sci (1971) 68, 736-739.
4) Steiner AL, Parker CW and Kipnis DM : Radioimmunoassay for cyclic nucleotides. J Biol Chem (1972) 247, 1106-1113.
5) 村山俊彦, 宇井理生 : 細胞における情報伝達c-AMPを介する機構. 代謝 (1986) 23, 271-276.
6) 三木直正 : 細胞における情報伝達c-GMPを介する機構. 代謝 (1986) 23, 277-280.
7) 橋本虎六, 今井昭一, 村山俊彦 : Cyclic AMPの現状と展望. 最新医学 (1985) 40, 235-349.
8) 村山俊彦, 今井理生 : 細胞ー細胞間の情報伝達. 神経精神薬理 (1986) 8, 513-543.
9) 根岸 学, 伊菜誠二 : プロスタグランジン受容体とGPT結合蛋白質. 実験医学 (1988) 6, 1140-1144.
10) Zelig CE and Goldberg ND : Cell-cycle related changes of 3',5'-cyclic GMP levels in Novikoff hepatoma cells. Proc Natl Acad Sci (1977) 74, 1052-1056.
11) Peracchi M, Lombardi L, Toschi V, Bamonticatena F and Mandeli V : Plasma and urine cyclic nucleotide levels in patiests with noplastic disease. Cancer (1984) 54, 3028-3034.
12) Wood PJ, Pao G and Cooper A : Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia. Cancer (1984) 53, 79-82.
13) Takemoto DJ, Kresie R and Vaughn D : Partial purification and characterization of a guanylate cyclase inhibit or with cytotoxic properties from the bitter melon (Momordica Charantia). Biochem Biophys Res Commun (1980) 94, 332-3339.
14) 上代淑人 : 細胞シグナル伝達系と癌. 日本医誌会雑誌 (1986) 96, 937-943.
15) 渋谷正史 : オンコジン蛋白の構造と機能. 病態生理 (1986) 5, 762-768.
16) 豊島久真男 : レトロウイルス癌遺伝子と細胞癌遺伝子. 日本臨床 (1990) 48, 8-12.
17) 平井久丸 : 造血器腫瘍における遺伝子変化. 最新医学 (1992) 47, 419-425.
18) 宇野 功 : 癌遺伝子rasファミリー. 代謝 (1987) 24, 495-503.
19) 福井泰久 : 酵母のras遺伝子. 医学のあゆみ (1985) 133, 1105-1108.
20) 宇野 功 : 酵母のras遺伝子によるc-AMPカスケードの機能調節. 癌と化学療法 (1986) 13, 849-853.
21) 湯浅保仁 : Dr. Wigler, 宇野博士らの酵母における癌遺伝子rasの研究. Oncologia (1985) 14, 132-134.
22) 宇野 功 : 癌遺伝子と酵母細胞. 実験医学 (1986) 4, 291-295.
23) 玉井野冬彦, 藤山秋佐夫 : 酵母RASタンパク質の構造と機能. 細胞工学 (1985) 6, 744-752.
24) 清水憲二 : RAS蛋白質の現状. 実験医学 (1988) 6, 1171-1175.
25) 山本 雅 : 癌遺伝子と細胞増殖制御. 実験医学 (1988) 6, 391-399.
26) 木村喜代次, 太田和雄, 恒吉英雄 : 白血病の化学療法士の二, 三の知見について. 癌 (1957) 48, 496-498.
27) 宇野理生, 岡田文彦, 佐藤朝一 : サイクリックヌクレオチドの体内動態 ; 基礎と臨床, 医歯薬出版, 東京 (1984).
28) Minden MD, Till JE and McCulloch EA : Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML). Blood (1978) 52, 592-599.
29) 西村正隆 : 急性白血病並びに類縁疾患における造血幹細胞動態に関する研究. 第1編 急性白血病における Leukemic Blast Progenitors 由来コロニー形成能並びに形成パターンの検討. 岡山医誌 (1991) 103, 1147-1158.
30) Criss WE and Murad F : Urinary excretion of cyclic adenosine 3',5'-monophosphate and cyclic adenosine 3',5'-monophate in rats bearing transplantable liver and kidney tumors. Cancer Res (1976) 36, 1714-1716.
31) Chawla RK, Nixon DW, Shoji M and Rudman D : Plasma and urine cyclic guanosine 3',5'-monophos-phate in disseminated cancer, Ann Intern Med (1979) 91, 862-864.
32) Takemoto DJ, Dunford C, Vaughn D, Kramer KJ, Smith A and Powell RG : Guanylate cylase activity in human leukemic and normal lymphocytes. Enzyme. (1982) 27, 179-188.
33) 高橋 功, 沖田浩之, 西村正隆, 青山重男, 喜多嶋康一, 木村郁郎, 真田 浩 : 低形成型白血病の病態・治療に関する検討. 第84回日本内科学会総会 (1987).
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma