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ID 14022
Eprint ID
14022
FullText URL
106_335.pdf 3.04 MB
Title Alternative
Ok-432-induced interferon-γ (IFN-γ) production in patients with malignant lymphoma
Author
Saito, Seiji
Abstract
OK-432, a streptococcal preparatopn, is a potent inducer of interferon-γ (IFN-γ) which is known to modulate the immune response. The OK-432-induced IFN-γ production of peripheral blood mononuclear cells (PBMC) was examined in 98 patients with malignant lymphoma, The PBMC were incubated in RPMI-1640 containing 0.1KE/ml OK-432 for 48 hours and the IFN-γ secreted in the supernatant was measured thereafter. Patients at diagnosis or those with relapsing disease showed a decreased production of IFN-γ compared with the healthy controls (P<0.001). The production at diagnosis was related to the clinical stage. The production was significantly decreased immediately after multi-drug chemotherapy. However, it recovered to the level of the healthy controls, once a patient achieved a complete response. At diagnosis, 13 of the 32 patients with non-Hodgkin's lymphoma showed low IFN-γ production. These patients responded poorly to chemotherapy or had early relapse. The 2-year actuarial survival rate was 54% for these patients and 92% for the remainder. There was no decrease in IFN-γ production after chemotherapy in patients treated with G-CSF. These findings suggest that measurement of OK-432-induced IFN-γ production is useful for evaluating the immunological status and predicting the prognosis in patients with malignant lymphoma. They also suggest that G-CSF affects the IFN-γ production in vivo.
Keywords
Lymphoma
G-CSF
Prognostic factor
Note
原著
Published Date
1994
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
335
End Page
347
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/3-4/106_3-4_335/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma