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ID 13864
Eprint ID
13864
FullText URL
Thumnail 106_1117.pdf 1.28 MB
Title Alternative
Effect of isoflurane on energy status of isolated hepatocytes
Author
Samuta, Takeshi
Abstract
We investigated the variation in the protection of energy status by isoflurane in isolated hepatocytes with the isoflurane dose, duration of anoxia, and reoxygenation by measurements of ATP, ADP, and AMP, in the cells. During 30 min of anoxia, in the presence of 1.4, 2.8, 4.2% isoflurane the ATP concentration was more than that with 0% isoflurane. With a 30-35 min incubation in the presence of 1.4% isoflurane, there was a modest decrease in energy charge during anoxia, partially prevented by isoflurane and completely reversed by reoxygenation, and no decrease in the total adenine nucleotide. With a 90-120 min incubation, isoflurane partly prevented the decreases in both energy charge and total adenine nucleotide during both anoxia and reoxygenation. We conclude that at doses in the clinical range, isoflurane partially protected isolated hepatocytes against decreases in both energy charge and total adenine nucleotide occurring either during short or long anoxia.
Keywords
イソフルラン
分離肝細胞
エネルギーチャージ
高エネルギーリン酸化合物
Note
原著
Published Date
1994-12
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume106
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1117
End Page
1124
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/106/11-12/106_11-12_1117/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma