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ID 13773
Eprint ID
13773
FullText URL
Thumnail 108_31.pdf 2.98 MB
Title Alternative
The effects of enflurane on hepatic microaomal cytochrome P-450
Author
Ishikawa, Masami
Abstract
The effects of enflurane and pretratment with phenobarbital or pyridine on hepatic cytochrome P-450(P-450) were studied in mele rats. The rats without pretreatment and those pretreated with phenobarbital or pyridine, were fasted for 24 hours and exposed to 1.2% enflurane at 10% or 21% oxygen for 2 hours. Each group consisted of 6 rets, and rats that were not exposed to enflurane served as control. In the group of rats pretreated with pyridine and exposed to enflurane at 10% oxygen, the content of P-450 and activity of aniline hydroxylation decreased significantly to approximately 61% and 62% of those of the control, respectively. Increases in the plasma level of AST and ALT, and centrilobular necrosis in hepatic tissue were also seen in this group. Administration of disulfuram to rats pretreated with pyridine inhibited the decrease of P-450 and hepatic injury. Threse results indicate that P-450 induced by pyridine was decomposed by exposure to enflurane at 10% oxygen and might cause hepatic injury.
Keywords
エンフルラン
酵素誘導
チトクロームP-450
肝障害
Note
原著
Published Date
1996-02-29
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume108
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
31
End Page
42
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/108/1-2/108_1-2_31/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma