このエントリーをはてなブックマークに追加
ID 13713
Eprint ID
13713
FullText URL
108_117.pdf 623 KB
Title Alternative
Erythromycin therapy in patients with diffuse panbronchiolitis
Author
Fukuda, Tomoko
Abstract
Low dose and long-term erythromycin (EM) therapy showed obvious improvement of symptoms and prognosis in patients with DPB. However, mechanisms involved in these clinical effects of EM therapy remain controversial. In this study, the clinical effects of EM therapy on respiratory function, bacterial flora in the lower airway and serum levels of soluble IL-2 receptor (sIL-2R) as an indicator of T-cell activation were examined. All parameters of respiratory functions in patients with DPB including % VC, % FEV 1.0, % V50, % V25 and V50/V25 showed marked improvements within 6 months of EM therapy. Continuous administration of EM for 6 to 24 months produced minimal changes in these respiratory functions though decreases in some parameters were observed in patients with advanced clinical stage and in eldely patients. The increase of % FEV 1.0 exceeded those of % V50 and % V25 after EM therapy. This indicates severe pathological changes in small airways or variable effects of EM therapy. Bacterial species and sensitivities to antibiotics showed no apparent changes after long-term EM therapy. The serum levels of sIL-2R in patients with DPB were higher than those in normal controls. With EM therapy, serum levels of sIL-2R decreased rapidly within 6 months, but these levels remained higher than those in normal controls, even after long-term EM therapy.
Keywords
diffuse panbronchiolitis
erythromycin
呼吸機能
soluble IL-2 reseptor
喀痰中細菌叢
Note
原著
Published Date
1996-06-29
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume108
Issue
issue3-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
117
End Page
127
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_117/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma