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ID 11867
Eprint ID
11867
FullText URL
Title Alternative
Reactivity and stability of propentdyopent produced by the oxidative cleavage of hemin
Author
Hirota, Kazuhiro
Abstract
The water adduct of propentdyopent, which have two propionic acid groups and two methyl groups on two pyrrole rings and a hydroxyl group at the valley position, was prepared by the oxidation of hemin with hydrogen peroxide. Esterification of the two propionic acid groups and substitution of alkoxy group for the hydroxy group were studied to examine the reactivity of the adduct. The esterification took place with the substitution of methoxy group on treatment with a solution of 2% sulfuric acid in methanol at 60℃. The substitutions of methoxy and ethoxy groups were attained without any esterification on treatment with a solution 10% acetic in methanol at 80℃ and a solution of 10% acetic acid in ethanol, respectively. Only esterification was performed on treatment with an ethereal solution of diazomethane. Hydrolysis of the ester occurred simultaneously with the substitution of hydroxyl group for methoxy group on standing with 0.5N hydrochloric acid at room temperature. Those compounds were purified by thin-layer chromatography and identified with mass and nmr spectra.
Keywords
Propentdyopent
pentdyopent
hemin
oxidation
dipyrrole
Published Date
1994-01-31
Publication Title
岡山大学医療技術短期大学部紀要
Publication Title Alternative
Bulletin of School of Health Sciences Okayama University
Volume
volume4
Publisher
岡山大学医療技術短期大学部
Publisher Alternative
School of Health Sciences Okayama University
Start Page
31
End Page
36
ISSN
0917-4494
NCID
AN10355371
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
fhs